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Research progress on FASN and MGLL in the regulation of abnormal lipid metabolism and the relationship

Jingyue Zhang, Yawen Song, Qianqian Shi, Li Fu

Frontiers of Medicine 2021, Volume 15, Issue 5,   Pages 649-656 doi: 10.1007/s11684-021-0830-0

Abstract: Tumorigenesis involves metabolic reprogramming and abnormal lipid metabolism, which is manifested byBoth enzymes play an important role in lipid metabolism and are associated with tumor-related signalingarticle introduces the structures and functions of FASN and MGLL, their relationship with abnormal lipidmetabolism, and the mechanism of the regulation of tumor invasion and metastasis and reviews the research

Keywords： FASN     MGLL     lipid metabolism     tumor invasion     metastasis    

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Zooming in and out of ferroptosis in human disease

Frontiers of Medicine 2023, Volume 17, Issue 2,   Pages 173-206 doi: 10.1007/s11684-023-0992-z

Abstract: Ferroptosis is defined as an iron-dependent regulated form of cell death driven by lipid peroxidation

Keywords： ferroptosis     human disease     iron metabolism     lipid peroxidation     antioxidation    

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Light-Responsive Gene BcCfaS Regulates the Photomorphogenesis and Virulence of Botrytis cinerea via LipidMetabolism

Guangjin Li,Zhanquan Zhang,Yong Chen,Tong Chen,Boqiang Li,Shiping Tian,

Engineering doi: 10.1016/j.eng.2023.08.015

Abstract: Thus, we propose that BcCfaS serves as an integration node for light and lipid metabolism, thereby providing

Keywords： Light     Botrytis cinerea     Cyclopropane fatty-acyl-phospholipid synthase     Lipid metabolism     Photomorphogenesis    

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Bioactive Components of Chinese Herbal Medicines in the Treatment of Glucose and Lipid Metabolism Disorders Review

Ying Zhang, Jiaming Ju, Lei Jiao, Baofeng Yang

Engineering 2023, Volume 29, Issue 10,   Pages 73-82 doi: 10.1016/j.eng.2023.03.004

Abstract:

Disturbed cholesterol and glucose homeostasis play crucial roles in the development of various diseases such as cardiovascular diseases, cerebrovascular diseases, central nervous system diseases, and cancer. An increasing number of studies have shown that excessive body fat accumulation is associated with type 2 diabetes or insulin resistance in a vicious cycle. This vicious cycle promotes the occurrence and development of the aforementioned diseases. Therefore, stabilizing the blood lipids and blood glucose of patients is the predominant strategy for improving the symptoms of patients with cardiovascular, cerebrovascular, and central nervous system diseases. Traditional Chinese medicine, mainly Chinese herbal medicine (CHM), has a history of more than 2000 years in China, which has established a unique theory and accumulated a great wealth of clinical experience. Moreover, CHM has been widely used in China and other countries for the treatment of cardiovascular and cerebrovascular diseases, with the advantages of preventing and curing hyperlipidemia, diabetes, hypertension, and other diseases. However, the use of CHM in Western countries remains rather limited, partly because of the incomplete understanding of multiple complex components and uncertain pharmacological mechanisms. Herein, we review and discuss the benefits, molecular mechanisms, and clinical research progress of bioactive components of CHM and their preparations as therapeutics for hyperlipidemia and hyperglycemia.

Keywords： Chinese herbal medicines     Hyperlipidemia     Hyperglycemia     Cardiovascular and cerebrovascular diseases    

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and characterization of eight freshwater green algae strains for synchronous water purification and lipid

Jingjing ZHAN,Qiao ZHANG,Momei QIN,Yu HONG

Frontiers of Environmental Science & Engineering 2016, Volume 10, Issue 3,   Pages 548-558 doi: 10.1007/s11783-016-0831-4

Abstract: objective of this study is to select and characterize the candidate for synchronous water purification and lipidsuperiority in biomass accumulation, while the top biomass producers did not correspond to the top lipidachieved higher lipid content (66.1%), and sp.HQ and ranked down in sequence, with lipid content above 30%.HQ was the possible candidate for water purification coupled with lipid production.

Keywords： freshwater microalgae     biomass production     lipid accumulation     nutrient removal    

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Proteins moonlighting in tumor metabolism and epigenetics

Lei Lv, Qunying Lei

Frontiers of Medicine 2021, Volume 15, Issue 3,   Pages 383-403 doi: 10.1007/s11684-020-0818-1

Abstract: The signal−moonlighting protein−metabolism axis facilitates the adaptation of tumor cells under varying

Keywords： moonlighting function     tumor metabolism     epigenetics    

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Trends in serum lipid levels of healthy Chinese in Shanghai from 1973 to 1999

CHEN Haozhu, ZHOU Jun, CHEN Bin, ZHUANG Hanzhong, JIN Xuejuan, HAN Qingqing

Frontiers of Medicine 2008, Volume 2, Issue 1,   Pages 5-10 doi: 10.1007/s11684-008-0002-5

Abstract: We assessed the secular trends in the serum lipid levels in Shanghai residents from 1973 to 1999.four independent, cross-sectional, population-based surveys were used to analyze the trends in serum lipidSerum lipid levels were measured in a single laboratory throughout the entire study period.A non-significant increase was noted from 1973–1974 to 1982–1983 in the serum lipid profiles; however
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The role of lipids in fermentative propionate production from the co-fermentation of lipid and food waste

Frontiers of Environmental Science & Engineering 2023, Volume 17, Issue 7, doi: 10.1007/s11783-023-1686-0

Abstract:

● Lipid can promote PA production on a target from food waste.

Keywords： Acidogenic fermentation     Microbial community     Volatile fatty acid     Propionate     Food waste     Lipid    

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Repeated batch fermentation with water recycling and cell separation for microbial lipid production

Yumei WANG, Wei LIU, Jie BAO

Frontiers of Chemical Science and Engineering 2012, Volume 6, Issue 4,   Pages 453-460 doi: 10.1007/s11705-012-1210-8

Abstract: Large waste water disposal was the major problem in microbial lipid fermentation because of low yieldof lipid.this study, the repeated batch fermentation was investigated for reducing waste water generated in the lipidThe result showed that at least 70% of the waste water was reduced, while lipid production maintainedOur method provided a practical option for reducing the waste water generated from microbial lipid fermentation

Keywords： batch fermentation     microbial lipid     Trichosporon cutaneum CX1     flocculation     waste water    

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Relationship of endothelial nitric oxide synthase gene polymorphism with blood pressure, lipid profile

TANG Zhongzhi, LI Junyao, YANG Jianhong

Frontiers of Medicine 2008, Volume 2, Issue 2,   Pages 178-181 doi: 10.1007/s11684-008-0033-y

Abstract: relationship of the polymorphism of endothelial nitric oxide synthase (eNOS) gene and blood pressure, lipidindividuals with serum TC above 5.4 mmol/L ( = 0.03, = 2.65). eNOS Glu298Asp polymorphism and serum lipid
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Comparison of growth and lipid accumulation properties of two oleaginous microalgae under different nutrient

Qiao ZHANG,Yu HONG

Frontiers of Environmental Science & Engineering 2014, Volume 8, Issue 5,   Pages 703-709 doi: 10.1007/s11783-014-0649-x

Abstract: This study compared the growth and lipid accumulation properties of two oleaginous microalgae, namelyBoth algal species obtained the highest biomass, lipid content and lipid yield under low-nutrient conditionsThe biomass, lipid content and lipid yield of sp.Opposite results were observed in lipid and triacylglycerols (TAGs) contents.In summary, low-nutrient conditions favour the growth and lipid production of both algae, but sp.

Keywords： HQ     growth rate     algal biomass     lipid accumulation     triacylglycerols (TAGs)    

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Vanadium metabolism investigation using substance flow and scenario analysis

Fangfang ZHANG, Huiquan LI, Bo CHEN, Xue GUAN, Yi ZHANG

Frontiers of Environmental Science & Engineering 2014, Volume 8, Issue 2,   Pages 256-266 doi: 10.1007/s11783-013-0585-1

Abstract: Vanadium is a vital strategic resource, and vanadium metabolism is an important part of the nationalThis study conducts accounting and scenario analysis on the life cycle of vanadium metabolism in ChinaA scenario analysis was conducted to analyze the future developmental trend of vanadium metabolism in

Keywords： metabolism     vanadium industry     substance flow analysis     scenario analysis    

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Insulin resistance and the metabolism of branched-chain amino acids

Jingyi Lu, Guoxiang Xie, Weiping Jia, Wei Jia

Frontiers of Medicine 2013, Volume 7, Issue 1,   Pages 53-59 doi: 10.1007/s11684-013-0255-5

Abstract: particularly responsive to the inhibitory insulin action on amino acid release by skeletal muscle and their metabolism

Keywords： branched-chain amino acids     leucine     isoleucine     valine     insulin resistance    

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Anaerobic ammonia oxidizing bacteria: ecological distribution, metabolism, and microbial interactions

Dawen Gao, Xiaolong Wang, Hong Liang, Qihang Wei, Yuan Dou, Longwei Li

Frontiers of Environmental Science & Engineering 2018, Volume 12, Issue 3, doi: 10.1007/s11783-018-1035-x

Abstract: Anammox (ANaerobic AMMonia OXidation) is a newly discovered pathway in the nitrogen cycle. This discovery has increased our knowledge of the global nitrogen cycle and triggered intense interest for anammox-based applications. Anammox bacteria are almost ubiquitous in the suboxic zones of almost all types of natural ecosystems and contribute significant to the global total nitrogen loss. In this paper, their ecological distributions and contributions to the nitrogen loss in marine, wetland, terrestrial ecosystems, and even extreme environments were reviewed. The unique metabolic mechanism of anammox bacteria was well described, including the particular cellular structures and genome compositions, which indicate the special evolutionary status of anammox bacteria. Finally, the ecological interactions among anammox bacteria and other organisms were discussed based on substrate availability and spatial organizations. This review attempts to summarize the fundamental understanding of anammox, provide an up-to-date summary of the knowledge of the overall anammox status, and propose future prospects for anammox. Based on novel findings, the metagenome has become a powerful tool for the genomic analysis of communities containing anammox bacteria; the metabolic diversity and biogeochemistry in the global nitrogen budget require more comprehensive studies.

Keywords： Anammox     Metabolism     Metagenome     Ecological distribution     Microbial interactions    

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Metabolism and immunity in breast cancer

Deyu Zhang, Xiaojie Xu, Qinong Ye

Frontiers of Medicine 2021, Volume 15, Issue 2,   Pages 178-207 doi: 10.1007/s11684-020-0793-6

Abstract: Breast cancer cells generate energy through increased glucose metabolism.Lipid metabolism contributes to biological signal pathways and forms cell membranes except energy generationHere, we review the recent findings related to abnormal metabolism and immune characteristics, regulatory

Keywords： breast cancer     metabolism     immunity     cancer stem cells    

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Title Author Date Type Operation

Research progress on FASN and MGLL in the regulation of abnormal lipid metabolism and the relationship

Jingyue Zhang, Yawen Song, Qianqian Shi, Li Fu

Journal Article

Zooming in and out of ferroptosis in human disease

Journal Article

Light-Responsive Gene BcCfaS Regulates the Photomorphogenesis and Virulence of Botrytis cinerea via LipidMetabolism

Guangjin Li,Zhanquan Zhang,Yong Chen,Tong Chen,Boqiang Li,Shiping Tian,

Journal Article

Bioactive Components of Chinese Herbal Medicines in the Treatment of Glucose and Lipid Metabolism Disorders

Ying Zhang, Jiaming Ju, Lei Jiao, Baofeng Yang

Journal Article

and characterization of eight freshwater green algae strains for synchronous water purification and lipid

Jingjing ZHAN,Qiao ZHANG,Momei QIN,Yu HONG

Journal Article

Proteins moonlighting in tumor metabolism and epigenetics

Lei Lv, Qunying Lei

Journal Article

Trends in serum lipid levels of healthy Chinese in Shanghai from 1973 to 1999

CHEN Haozhu, ZHOU Jun, CHEN Bin, ZHUANG Hanzhong, JIN Xuejuan, HAN Qingqing

Journal Article

The role of lipids in fermentative propionate production from the co-fermentation of lipid and food waste

Journal Article

Repeated batch fermentation with water recycling and cell separation for microbial lipid production

Yumei WANG, Wei LIU, Jie BAO

Journal Article

Relationship of endothelial nitric oxide synthase gene polymorphism with blood pressure, lipid profile

TANG Zhongzhi, LI Junyao, YANG Jianhong

Journal Article

Comparison of growth and lipid accumulation properties of two oleaginous microalgae under different nutrient

Qiao ZHANG,Yu HONG

Journal Article

Vanadium metabolism investigation using substance flow and scenario analysis

Fangfang ZHANG, Huiquan LI, Bo CHEN, Xue GUAN, Yi ZHANG

Journal Article

Insulin resistance and the metabolism of branched-chain amino acids

Jingyi Lu, Guoxiang Xie, Weiping Jia, Wei Jia

Journal Article

Anaerobic ammonia oxidizing bacteria: ecological distribution, metabolism, and microbial interactions

Dawen Gao, Xiaolong Wang, Hong Liang, Qihang Wei, Yuan Dou, Longwei Li

Journal Article

Metabolism and immunity in breast cancer

Deyu Zhang, Xiaojie Xu, Qinong Ye

Journal Article